diff --git a/src/qemu/qemu_domain.c b/src/qemu/qemu_domain.c
index 5cb5ac801f..1659e88478 100644
--- a/src/qemu/qemu_domain.c
+++ b/src/qemu/qemu_domain.c
@@ -3474,6 +3474,26 @@ qemuDomainDefAddDefaultDevices(virDomainDefPtr def,
         virQEMUCapsGet(qemuCaps, QEMU_CAPS_VIRTIO_S390) && def->memballoon)
         def->memballoon->model = VIR_DOMAIN_MEMBALLOON_MODEL_NONE;
 
+    if (addDefaultUSBMouse) {
+        bool hasUSBTablet = false;
+        size_t j;
+
+        for (j = 0; j < def->ninputs; j++) {
+            if (def->inputs[j]->type == VIR_DOMAIN_INPUT_TYPE_TABLET &&
+                def->inputs[j]->bus == VIR_DOMAIN_INPUT_BUS_USB) {
+                hasUSBTablet = true;
+                break;
+            }
+        }
+
+        /* Historically, we have automatically added USB keyboard and
+         * mouse to some guests. While the former device is generally
+         * safe to have, adding the latter is undesiderable if a USB
+         * tablet is already present in the guest */
+        if (hasUSBTablet)
+            addDefaultUSBMouse = false;
+    }
+
     if (addDefaultUSBKBD &&
         def->ngraphics > 0 &&
         virDomainDefMaybeAddInput(def,
diff --git a/tests/qemuxml2argvdata/ppc64-pseries-graphics.ppc64-latest.args b/tests/qemuxml2argvdata/ppc64-pseries-graphics.ppc64-latest.args
index 1c6c25ed24..b81648f078 100644
--- a/tests/qemuxml2argvdata/ppc64-pseries-graphics.ppc64-latest.args
+++ b/tests/qemuxml2argvdata/ppc64-pseries-graphics.ppc64-latest.args
@@ -37,7 +37,6 @@ addr=0x1 \
 id=channel0,name=org.qemu.guest_agent.0 \
 -device usb-tablet,id=input0,bus=usb.0,port=1 \
 -device usb-kbd,id=input1,bus=usb.0,port=2 \
--device usb-mouse,id=input2,bus=usb.0,port=3 \
 -vnc 127.0.0.1:0 \
 -device VGA,id=video0,vgamem_mb=16,bus=pci.0,addr=0x7 \
 -device virtio-balloon-pci,id=balloon0,bus=pci.0,addr=0x5 \