diff --git a/src/qemu/qemu_domain_address.c b/src/qemu/qemu_domain_address.c
index 10cf5eb6f4..93942be559 100644
--- a/src/qemu/qemu_domain_address.c
+++ b/src/qemu/qemu_domain_address.c
@@ -421,9 +421,6 @@ qemuDomainAssignS390Addresses(virDomainDef *def,
         if (!(addrs = virDomainCCWAddressSetCreateFromDomain(def)))
             goto cleanup;
 
-    } else if (virQEMUCapsGet(qemuCaps, QEMU_CAPS_VIRTIO_S390)) {
-        /* deal with legacy virtio-s390 */
-        qemuDomainPrimeVirtioDeviceAddresses(def, VIR_DOMAIN_DEVICE_ADDRESS_TYPE_VIRTIO_S390);
     }
 
     ret = 0;
@@ -3271,8 +3268,6 @@ qemuDomainEnsureVirtioAddress(bool *releaseAddr,
         if (qemuDomainIsS390CCW(vm->def) &&
             virQEMUCapsGet(priv->qemuCaps, QEMU_CAPS_CCW))
             info->type = VIR_DOMAIN_DEVICE_ADDRESS_TYPE_CCW;
-        else if (virQEMUCapsGet(priv->qemuCaps, QEMU_CAPS_VIRTIO_S390))
-            info->type = VIR_DOMAIN_DEVICE_ADDRESS_TYPE_VIRTIO_S390;
     } else {
         if (!qemuDomainCheckCCWS390AddressSupport(vm->def, info, priv->qemuCaps,
                                                   devicename))
diff --git a/src/qemu/qemu_validate.c b/src/qemu/qemu_validate.c
index 75e3db6ca9..d0b73f2bfb 100644
--- a/src/qemu/qemu_validate.c
+++ b/src/qemu/qemu_validate.c
@@ -1309,11 +1309,15 @@ qemuValidateDomainDeviceDefAddress(const virDomainDeviceDef *dev,
         break;
         }
 
+    case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_VIRTIO_S390:
+        virReportError(VIR_ERR_CONFIG_UNSUPPORTED, "%s",
+                       _("'virtio-s390' addresses are no longer supported"));
+        return -1;
+
     case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_DRIVE:
     case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_VIRTIO_SERIAL:
     case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_CCID:
     case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_USB:
-    case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_VIRTIO_S390:
     case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_CCW:
     case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_VIRTIO_MMIO:
     case VIR_DOMAIN_DEVICE_ADDRESS_TYPE_ISA: