diff --git a/target/product/core_64_bit.mk b/target/product/core_64_bit.mk
index 5d7abcb75..a21620c2a 100644
--- a/target/product/core_64_bit.mk
+++ b/target/product/core_64_bit.mk
@@ -37,3 +37,6 @@ TARGET_PREFER_32_BIT_APPS := true
 
 TARGET_SUPPORTS_32_BIT_APPS := true
 TARGET_SUPPORTS_64_BIT_APPS := true
+
+# Disable DEXPREOPT until we have multilib support (bug 14694978).
+WITH_DEXPREOPT := false